Understanding CLDN18.2: The Target of VYLOY Injection in India
Cancer treatment has evolved significantly, with targeted therapies offering new hope for patients with advanced malignancies. One such innovation is the focus on CLDN18.2, a tight junction protein playing a pivotal role in tumor growth and progression. The emergence of CLDN18.2-targeted therapies has led to the development of advanced biologics like VYLOY Injection in India, offering a novel approach to managing difficult-to-treat cancers. Understanding CLDN18.2 CLDN18.2 (Claudin 18.2) is a membrane protein belonging to the claudin family, which is crucial for maintaining tight junctions in epithelial cells. Under normal physiological conditions, CLDN18.2 expression is predominantly restricted to gastric mucosa cells. However, in cancerous conditions, particularly in gastric, pancreatic, and esophageal cancers, CLDN18.2 becomes aberrantly expressed, making it a viable target for antibody-based therapies. The overexpression of CLDN18.2 in malignant cells while remaining largely ab...